Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes

Pathogenic mycobacteria contain up to five type VII secretion (T7S) systems, ESX-1 to ESX-5. One of the conserved T7S components is the serine protease mycosin (MycP). Strikingly, whereas MycP is essential for secretion, the protease activity of MycP(1) in Mycobacterium tuberculosis has been shown t...

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Pubblicato in:mBio
Autori principali: van Winden, Vincent J. C., Ummels, Roy, Piersma, Sander R., Jiménez, Connie R., Korotkov, Konstantin V., Bitter, Wilbert, Houben, Edith N. G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082899/
https://ncbi.nlm.nih.gov/pubmed/27795391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01471-16
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