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Interaction between Darunavir and Etravirine Is Partly Mediated by CYP3A5 Polymorphism
OBJECTIVES: To assess the impact of the loss-of-function CYP3A5*3 allele (rs776746, 6986A>G SNP) on darunavir (DRV) plasma concentrations. METHODS: 135 HIV-1 infected patients treated with DRV-based therapy were included in the study and plasma samples were obtained immediately before drug intake...
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| Gepubliceerd in: | PLoS One |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5082792/ https://ncbi.nlm.nih.gov/pubmed/27788239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165631 |
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