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Effect of ABCB1 genetic polymorphisms on the transport of rivaroxaban in HEK293 recombinant cell lines

Direct oral anticoagulants (DOAC) are substrates for the ABCB1 transporter (also called P-glycoprotein), an active efflux pump. ABCB1 polymorphisms have been previously reported to influence the pharmacokinetics of several drugs such as immunosuppressants and tyrosine kinase inhibitors. Recently, in...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Sennesael, Anne-Laure, Panin, Nadtha, Vancraeynest, Christelle, Pochet, Lionel, Spinewine, Anne, Haufroid, Vincent, Elens, Laure
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6043481/
https://ncbi.nlm.nih.gov/pubmed/30002384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28622-4
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