Interaction between Darunavir and Etravirine Is Partly Mediated by CYP3A5 Polymorphism

OBJECTIVES: To assess the impact of the loss-of-function CYP3A5*3 allele (rs776746, 6986A>G SNP) on darunavir (DRV) plasma concentrations. METHODS: 135 HIV-1 infected patients treated with DRV-based therapy were included in the study and plasma samples were obtained immediately before drug intake...

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Опубликовано в: :PLoS One
Главные авторы: Belkhir, Leïla, Elens, Laure, Zech, Francis, Panin, Nadtha, Vincent, Anne, Yombi, Jean Cyr, Vandercam, Bernard, Haufroid, Vincent
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082792/
https://ncbi.nlm.nih.gov/pubmed/27788239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165631
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