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Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration

PURPOSE: To redesign a complement-inhibiting peptide with the potential to become a therapeutic for dry and wet age-related macular degeneration (AMD). METHODS: We present a new potent peptide (Peptide 2) of the compstatin family. The peptide is developed by rational design, based on a mechanistic b...

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Vydáno v:Mol Vis
Hlavní autoři: Mohan, Rohith R., Cabrera, Andrea P., Harrison, Reed E. S., Gorham, Ronald D., Johnson, Lincoln V., Ghosh, Kaustabh, Morikis, Dimitrios
Médium: Artigo
Jazyk:Inglês
Vydáno: Molecular Vision 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082644/
https://ncbi.nlm.nih.gov/pubmed/27829783
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