Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration

PURPOSE: To redesign a complement-inhibiting peptide with the potential to become a therapeutic for dry and wet age-related macular degeneration (AMD). METHODS: We present a new potent peptide (Peptide 2) of the compstatin family. The peptide is developed by rational design, based on a mechanistic b...

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Udgivet i:Mol Vis
Main Authors: Mohan, Rohith R., Cabrera, Andrea P., Harrison, Reed E. S., Gorham, Ronald D., Johnson, Lincoln V., Ghosh, Kaustabh, Morikis, Dimitrios
Format: Artigo
Sprog:Inglês
Udgivet: Molecular Vision 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082644/
https://ncbi.nlm.nih.gov/pubmed/27829783
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