The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets.

Activation of the classical mitogen-activated protein kinase (MAPK) pathway leads to proliferation of many cell types. Accordingly, an inhibitor of MAPK kinase, PD 098059, inhibits PDGF-induced proliferation of human arterial smooth muscle cells (SMCs) that do not secrete growth-inhibitory PGs such...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Bornfeldt, K E, Campbell, J S, Koyama, H, Argast, G M, Leslie, C C, Raines, E W, Krebs, E G, Ross, R
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1997
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508260/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9259587/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119603
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