Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

Stimulation of aortic smooth muscle cells with platelet-derived growth factor BB homodimer (PDGF-BB) leads to the rapid activation of mitogen-activated protein kinase (MAPK) and MAPK kinase (MAPKK). Compounds that increase cAMP and activate protein kinase A (PKA)--prostaglandin E2, isoproterenol, ch...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Graves, L M, Bornfeldt, K E, Raines, E W, Potts, B C, Macdonald, S G, Ross, R, Krebs, E G
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47762/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7694289/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.21.10300
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