The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets.

Activation of the classical mitogen-activated protein kinase (MAPK) pathway leads to proliferation of many cell types. Accordingly, an inhibitor of MAPK kinase, PD 098059, inhibits PDGF-induced proliferation of human arterial smooth muscle cells (SMCs) that do not secrete growth-inhibitory PGs such...

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Detalhes bibliográficos
Main Authors: Bornfeldt, K E, Campbell, J S, Koyama, H, Argast, G M, Leslie, C C, Raines, E W, Krebs, E G, Ross, R
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC508260/
https://ncbi.nlm.nih.gov/pubmed/9259587
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