Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

Sickle cell disease (SCD) patients have low serum hemopexin (Hpx) levels due to chronic hemolysis. We hypothesized that in SCD mice, hepatic overexpression of hemopexin would scavenge the proximal mediator of vascular activation, heme, and inhibit inflammation and microvascular stasis. To examine th...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Vercellotti, Gregory M, Zhang, Ping, Nguyen, Julia, Abdulla, Fuad, Chen, Chunsheng, Nguyen, Phong, Nowotny, Carlos, Steer, Clifford J, Smith, Ann, Belcher, John D
Formato: Artigo
Idioma:Inglês
Publicado em: Feinstein Institute for Medical Research 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082291/
https://ncbi.nlm.nih.gov/pubmed/27451971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00063
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