Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

Sickle cell disease (SCD) patients have low serum hemopexin (Hpx) levels due to chronic hemolysis. We hypothesized that in SCD mice, hepatic overexpression of hemopexin would scavenge the proximal mediator of vascular activation, heme, and inhibit inflammation and microvascular stasis. To examine th...

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Publicat a:Mol Med
Autors principals: Vercellotti, Gregory M, Zhang, Ping, Nguyen, Julia, Abdulla, Fuad, Chen, Chunsheng, Nguyen, Phong, Nowotny, Carlos, Steer, Clifford J, Smith, Ann, Belcher, John D
Format: Artigo
Idioma:Inglês
Publicat: Feinstein Institute for Medical Research 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082291/
https://ncbi.nlm.nih.gov/pubmed/27451971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00063
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