Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states. Haptoglobin and hemopexin supplementation protect tiss...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Belcher, John D., Chen, Chunsheng, Nguyen, Julia, Abdulla, Fuad, Zhang, Ping, Nguyen, Hao, Nguyen, Phong, Killeen, Trevor, Miescher, Sylvia M., Brinkman, Nathan, Nath, Karl A., Steer, Clifford J., Vercellotti, Gregory M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919001/
https://ncbi.nlm.nih.gov/pubmed/29694434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196455
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