Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states. Haptoglobin and hemopexin supplementation protect tiss...

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Veröffentlicht in:PLoS One
Hauptverfasser: Belcher, John D., Chen, Chunsheng, Nguyen, Julia, Abdulla, Fuad, Zhang, Ping, Nguyen, Hao, Nguyen, Phong, Killeen, Trevor, Miescher, Sylvia M., Brinkman, Nathan, Nath, Karl A., Steer, Clifford J., Vercellotti, Gregory M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919001/
https://ncbi.nlm.nih.gov/pubmed/29694434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196455
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