Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states. Haptoglobin and hemopexin supplementation protect tiss...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Belcher, John D., Chen, Chunsheng, Nguyen, Julia, Abdulla, Fuad, Zhang, Ping, Nguyen, Hao, Nguyen, Phong, Killeen, Trevor, Miescher, Sylvia M., Brinkman, Nathan, Nath, Karl A., Steer, Clifford J., Vercellotti, Gregory M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919001/
https://ncbi.nlm.nih.gov/pubmed/29694434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196455
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