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Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice

Transgenic sickle mice expressing β(S) hemoglobin have activated vascular endothelium that exhibits enhanced expression of NF-κB and adhesion molecules that promote vascular stasis in sickle, but not in normal, mice in response to hypoxia/reoxygenation. Sickle mice hemolyze rbcs in vivo as demonstra...

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Autori principali: Belcher, John D., Mahaseth, Hemachandra, Welch, Thomas E., Otterbein, Leo E., Hebbel, Robert P., Vercellotti, Gregory M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366501/
https://ncbi.nlm.nih.gov/pubmed/16485041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26857
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