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Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice
Transgenic sickle mice expressing β(S) hemoglobin have activated vascular endothelium that exhibits enhanced expression of NF-κB and adhesion molecules that promote vascular stasis in sickle, but not in normal, mice in response to hypoxia/reoxygenation. Sickle mice hemolyze rbcs in vivo as demonstra...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1366501/ https://ncbi.nlm.nih.gov/pubmed/16485041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26857 |
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