Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate

Aims: Heme derived from hemolysis is pro-oxidative and proinflammatory and promotes vaso-occlusion in murine models of sickle cell disease (SCD), suggesting that enhanced detoxification of heme may be beneficial. Nuclear factor erythroid-2-related factor-2 (Nrf2) transcription pathway is the princip...

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Dades bibliogràfiques
Publicat a:Antioxid Redox Signal
Autors principals: Belcher, John D., Chen, Chunsheng, Nguyen, Julia, Zhang, Ping, Abdulla, Fuad, Nguyen, Phong, Killeen, Trevor, Xu, Pauline, O'Sullivan, Gerry, Nath, Karl A., Vercellotti, Gregory M.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2017
Matèries:
Forum Original Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421647/
https://ncbi.nlm.nih.gov/pubmed/26914345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2015.6571
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