Critical role of C5a in sickle cell disease

Innate immune complement activation may contribute to sickle cell disease (SCD) pathogenesis. Ischemia-reperfusion physiology is a key component of the inflammatory and vaso-occlusive milieu in SCD and is associated with complement activation. C5a is an anaphylatoxin, a potent pro-inflammatory media...

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Udgivet i:Am J Hematol
Main Authors: Vercellotti, Gregory M., Dalmasso, Agustin P., Schaid, Terry R., Nguyen, Julia, Chen, Chunsheng, Ericson, Marna E., Abdulla F, Fuad, Killeen, Trevor, Lindorfer, Margaret A., Taylor, Ronald P., Belcher, John D.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6986874/
https://ncbi.nlm.nih.gov/pubmed/30569594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.25384
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