Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells

Recent evidence indicates that hemolysis in sickle cell disease (SCD) promotes inflammation via innate immune signaling through toll-like receptor 4 (TLR4). Free heme released by hemolyzed red blood cells can bind to myeloid differentiation factor-2 (MD-2) and activate TLR4 pro-inflammatory signalin...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Zhang, Ping, Nguyen, Julia, Abdulla, Fuad, Nelson, Alexander T., Beckman, Joan D., Vercellotti, Gregory M., Belcher, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033004/
https://ncbi.nlm.nih.gov/pubmed/33841413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.632709
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