Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease

Heme, released from red blood cells in sickle cell disease (SCD), interacts with toll-like receptor 4 (TLR4) to activate NF-κB leading to the production of cytokines and adhesion molecules which promote inflammation, pain, and vaso-occlusion. In SCD, TLR4 inhibition has been shown to modulate heme-i...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Beckman, Joan D., Abdullah, Fuad, Chen, Chunsheng, Kirchner, Rachel, Rivera-Rodriguez, Dormarie, Kiser, Zachary M., Nguyen, Aithanh, Zhang, Ping, Nguyen, Julia, Hebbel, Robert P., Belcher, John D., Vercellotti, Gregory M.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7851052/
https://ncbi.nlm.nih.gov/pubmed/33542720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.613278
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