Heme oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease

Increases in heme oxygenase-1 (HO-1) and administration of heme degradation products CO and biliverdin inhibit vascular inflammation and vasoocclusion in mouse models of sickle cell disease (SCD). In this study, an albumin (alb) promoter-driven Sleeping Beauty (SB) transposase plasmid with a wild-ty...

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Detalhes bibliográficos
Main Authors: Belcher, John D., Vineyard, Julie V., Bruzzone, Carol M., Chen, Chunsheng, Beckman, Joan D., Nguyen, Julia, Steer, Clifford J., Vercellotti, Gregory M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877767/
https://ncbi.nlm.nih.gov/pubmed/20306336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-010-0613-6
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