Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice

We describe a metabolic disorder characterized by lipodystrophy, hepatic steatosis, insulin resistance, severe diabetes, and growth retardation observed in mice carrying N-ethyl-N-nitrosourea (ENU)–induced mutations. The disorder was ascribed to a mutation of kelch repeat and BTB (POZ) domain contai...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhang, Zhao, Turer, Emre, Li, Xiaohong, Zhan, Xiaoming, Choi, Mihwa, Tang, Miao, Press, Amanda, Smith, Steven R., Divoux, Adeline, Moresco, Eva Marie Y., Beutler, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081616/
https://ncbi.nlm.nih.gov/pubmed/27708159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614467113
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