Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function

The SMCR8-WDR41-C9ORF72 complex is a regulator of autophagy and lysosomal function. Autoimmunity and inflammatory disease have been ascribed to loss-of-function mutations of Smcr8 or C9orf72 in mice. In humans, autoimmunity has been reported to precede amyotrophic lateral sclerosis caused by mutatio...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: McAlpine, William, Sun, Lei, Wang, Kuan-wen, Liu, Aijie, Jain, Ruchi, San Miguel, Miguel, Wang, Jianhui, Zhang, Zhao, Hayse, Braden, McAlpine, Sarah Grace, Choi, Jin Huk, Zhong, Xue, Ludwig, Sara, Russell, Jamie, Zhan, Xiaoming, Choi, Mihwa, Li, Xiaohong, Tang, Miao, Moresco, Eva Marie Y., Beutler, Bruce, Turer, Emre
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298088/
https://ncbi.nlm.nih.gov/pubmed/30442666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814753115
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