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C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling
Hexanucleotide expansion in an intron of the C9orf72 gene causes amyotrophic lateral sclerosis and frontotemporal dementia. However, beyond bioinformatics predictions that suggested structural similarity to folliculin, the Birt-Hogg-Dubé syndrome tumor suppressor, little is known about the normal fu...
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| Publicado no: | Mol Biol Cell |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5063613/ https://ncbi.nlm.nih.gov/pubmed/27559131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-01-0003 |
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