Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice

LPS-responsive beige-like anchor (LRBA) protein deficiency in humans causes immune dysregulation resulting in autoimmunity, inflammatory bowel disease (IBD), hypogammaglobulinemia, regulatory T (T(reg)) cell defects, and B cell functional defects, but the cellular and molecular mechanisms responsibl...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Kuan-wen, Zhan, Xiaoming, McAlpine, William, Zhang, Zhao, Choi, Jin Huk, Shi, Hexin, Misawa, Takuma, Yue, Tao, Zhang, Duanwu, Wang, Ying, Ludwig, Sara, Russell, Jamie, Tang, Miao, Li, Xiaohong, Murray, Anne R., Moresco, Eva Marie Y., Turer, Emre E., Beutler, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561264/
https://ncbi.nlm.nih.gov/pubmed/31097594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901407116
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados