Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

Successful cancer immunotherapy entails activation of innate immune receptors to promote dendritic cell (DC) maturation, antigen presentation, up-regulation of costimulatory molecules, and cytokine secretion, leading to activation of tumor antigen-specific cytotoxic T lymphocytes (CTLs). Here we scr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Ying, Su, Lijing, Morin, Matthew D., Jones, Brian T., Mifune, Yuto, Shi, Hexin, Wang, Kuan-wen, Zhan, Xiaoming, Liu, Aijie, Wang, Jianhui, Li, Xiaohong, Tang, Miao, Ludwig, Sara, Hildebrand, Sara, Zhou, Kejin, Siegwart, Daniel J., Moresco, Eva Marie Y., Zhang, Hong, Boger, Dale L., Beutler, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140543/
https://ncbi.nlm.nih.gov/pubmed/30150374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809232115
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