TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS

Structurally disparate molecules reportedly engage and activate Toll-like receptor (TLR) 4 and other TLRs, yet the interactions that mediate binding and activation by dissimilar ligands remain unknown. We describe Neoseptins, chemically synthesized peptidomimetics that bear no structural similarity...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Wang, Ying, Su, Lijing, Morin, Matthew D., Jones, Brian T., Whitby, Landon R., Surakattula, Murali M. R. P., Huang, Hua, Shi, Hexin, Choi, Jin Huk, Wang, Kuan-wen, Moresco, Eva Marie Y., Berger, Michael, Zhan, Xiaoming, Zhang, Hong, Boger, Dale L., Beutler, Bruce
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763747/
https://ncbi.nlm.nih.gov/pubmed/26831104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525639113
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