Discovery and Structure–Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists

Herein, we report studies leading to the discovery of the neoseptins and a comprehensive examination of the structure–activity relationships of this new class of small molecule mouse Toll-like receptor 4 (mTLR4) agonists. The compound class, which emerged from screening a α-helix mimetic library, st...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Morin, Matthew D., Wang, Ying, Jones, Brian T., Su, Lijing, Surakattula, Murali M. R. P., Berger, Michael, Huang, Hua, Beutler, Elliot K., Zhang, Hong, Beutler, Bruce, Boger, Dale L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882283/
https://ncbi.nlm.nih.gov/pubmed/27050713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00177
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