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Discovery and Structure–Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists
Herein, we report studies leading to the discovery of the neoseptins and a comprehensive examination of the structure–activity relationships of this new class of small molecule mouse Toll-like receptor 4 (mTLR4) agonists. The compound class, which emerged from screening a α-helix mimetic library, st...
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| 出版年: | J Med Chem |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4882283/ https://ncbi.nlm.nih.gov/pubmed/27050713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00177 |
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