IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice

Class-switch recombination (CSR) alters the Ig isotype to diversify antibody effector functions. IgD CSR is a rare event, and its regulation is poorly understood. We report that deficiency of 53BP1, a DNA damage-response protein, caused age-dependent overproduction of secreted IgD resulting from inc...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Choi, Jin Huk, Wang, Kuan-wen, Zhang, Duanwu, Zhan, Xiaowei, Wang, Tao, Bu, Chun-Hui, Behrendt, Cassie L., Zeng, Ming, Wang, Ying, Misawa, Takuma, Li, Xiaohong, Tang, Miao, Zhan, Xiaoming, Scott, Lindsay, Hildebrand, Sara, Murray, Anne R., Moresco, Eva Marie Y., Hooper, Lora V., Beutler, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321007/
https://ncbi.nlm.nih.gov/pubmed/28137874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621258114
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