Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40

We report a new immunodeficiency disorder in mice caused by a viable hypomorphic mutation of Snrnp40, an essential gene encoding a subunit of the U5 small nuclear ribonucleoprotein (snRNP) complex of the spliceosome. Snrnp40 is ubiquitous but strongly expressed in lymphoid tissue. Homozygous mutant...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Nat Immunol
Autores principales: Zhang, Duanwu, Yue, Tao, Choi, Jin Huk, Nair-Gill, Evan, Zhong, Xue, Wang, Kuan-wen, Zhan, Xiaoming, Li, Xiaohong, Choi, Mihwa, Tang, Miao, Quan, Jiexia, Hildebrand, Sara, Moresco, Eva Marie Y., Beutler, Bruce
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179765/
https://ncbi.nlm.nih.gov/pubmed/31427773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0464-4
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares