Mice Carrying a Hypomorphic Evi1 Allele Are Embryonic Viable but Exhibit Severe Congenital Heart Defects

The ecotropic viral integration site 1 (Evi1) oncogenic transcription factor is one of a number of alternative transcripts encoded by the Mds1 and Evi1 complex locus (Mecom). Overexpression of Evi1 has been observed in a number of myeloid disorders and is associated with poor patient survival. It is...

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Main Authors: Bard-Chapeau, Emilie A., Szumska, Dorota, Jacob, Bindya, Chua, Belinda Q. L., Chatterjee, Gouri C., Zhang, Yi, Ward, Jerrold M., Urun, Fatma, Kinameri, Emi, Vincent, Stéphane D., Ahmed, Sayadi, Bhattacharya, Shoumo, Osato, Motomi, Perkins, Archibald S., Moore, Adrian W., Jenkins, Nancy A., Copeland, Neal G.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2014
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937339/
https://ncbi.nlm.nih.gov/pubmed/24586749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089397
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