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Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis
The RUNX1/AML1 gene is the most frequently mutated gene in human leukemia. Conditional deletion of Runx1 in adult mice results in an increase of hematopoietic stem cells (HSCs), which serve as target cells for leukemia; however, Runx1(−/−) mice do not develop spontaneous leukemia. Here we show that...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society of Hematology
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2830765/ https://ncbi.nlm.nih.gov/pubmed/20008790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-232249 |
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