Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors

Development of tool molecules that inhibit Jumonji demethylases allows for the investigation of cancer-associated transcription. While scaffolds such as 2,4-pyridinedicarboxylic acid (2,4-PDCA) are potent inhibitors, they exhibit limited selectivity. To discover new inhibitors for the KDM4 demethyla...

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Publicat a:J Med Chem
Autors principals: Korczynska, Magdalena, Le, Daniel D., Younger, Noah, Gregori-Puigjané, Elisabet, Tumber, Anthony, Krojer, Tobias, Velupillai, Srikannathasan, Gileadi, Carina, Nowak, Radosław P., Iwasa, Eriko, Pollock, Samuel B., Torres, Idelisse Ortiz, Oppermann, Udo, Shoichet, Brian K., Fujimori, Danica Galonić
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080985/
https://ncbi.nlm.nih.gov/pubmed/26699912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01527
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