Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3

BACKGROUND: Trimethylation at histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3) controls gene activity during development and differentiation. Whether H3K4me3 and H3K27me3 changes dynamically in response to altered microenvironmental conditions, including low-oxygen conditions commonly present...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Prickaerts, Peggy, Adriaens, Michiel E., Beucken, Twan van den, Koch, Elizabeth, Dubois, Ludwig, Dahlmans, Vivian E. H., Gits, Caroline, Evelo, Chris T. A., Chan-Seng-Yue, Michelle, Wouters, Bradly G., Voncken, Jan Willem
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080723/
https://ncbi.nlm.nih.gov/pubmed/27800026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-016-0086-0
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