The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

Tumor hypoxia is a common microenvironmental factor that adversely influences tumor phenotype and treatment response. Cellular adaptation to hypoxia occurs through multiple mechanisms, including activation of the unfolded protein response (UPR). Recent reports have indicated that hypoxia activates a...

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Detalhes bibliográficos
Main Authors: Rouschop, Kasper M.A., van den Beucken, Twan, Dubois, Ludwig, Niessen, Hanneke, Bussink, Johan, Savelkouls, Kim, Keulers, Tom, Mujcic, Hilda, Landuyt, Willy, Voncken, Jan Willem, Lambin, Philippe, van der Kogel, Albert J., Koritzinsky, Marianne, Wouters, Bradly G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798689/
https://ncbi.nlm.nih.gov/pubmed/20038797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40027
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