Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

Hypoxia has recently been shown to activate the endoplasmic reticulum kinase PERK, leading to phosphorylation of eIF2α and inhibition of mRNA translation initiation. Using a quantitative assay, we show that this inhibition exhibits a biphasic response mediated through two distinct pathways. The firs...

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Detalhes bibliográficos
Main Authors: Koritzinsky, Marianne, Magagnin, Michaël G, van den Beucken, Twan, Seigneuric, Renaud, Savelkouls, Kim, Dostie, Josée, Pyronnet, Stéphane, Kaufman, Randal J, Weppler, Sherry A, Voncken, Jan Willem, Lambin, Philippe, Koumenis, Constantinos, Sonenberg, Nahum, Wouters, Bradly G
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1409715/
https://ncbi.nlm.nih.gov/pubmed/16467844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600998
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