Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

Hypoxia has recently been shown to activate the endoplasmic reticulum kinase PERK, leading to phosphorylation of eIF2α and inhibition of mRNA translation initiation. Using a quantitative assay, we show that this inhibition exhibits a biphasic response mediated through two distinct pathways. The firs...

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Detaylı Bibliyografya
Asıl Yazarlar: Koritzinsky, Marianne, Magagnin, Michaël G, van den Beucken, Twan, Seigneuric, Renaud, Savelkouls, Kim, Dostie, Josée, Pyronnet, Stéphane, Kaufman, Randal J, Weppler, Sherry A, Voncken, Jan Willem, Lambin, Philippe, Koumenis, Constantinos, Sonenberg, Nahum, Wouters, Bradly G
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2006
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1409715/
https://ncbi.nlm.nih.gov/pubmed/16467844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600998
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