Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

Hypoxia has recently been shown to activate the endoplasmic reticulum kinase PERK, leading to phosphorylation of eIF2α and inhibition of mRNA translation initiation. Using a quantitative assay, we show that this inhibition exhibits a biphasic response mediated through two distinct pathways. The firs...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Koritzinsky, Marianne, Magagnin, Michaël G, van den Beucken, Twan, Seigneuric, Renaud, Savelkouls, Kim, Dostie, Josée, Pyronnet, Stéphane, Kaufman, Randal J, Weppler, Sherry A, Voncken, Jan Willem, Lambin, Philippe, Koumenis, Constantinos, Sonenberg, Nahum, Wouters, Bradly G
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2006
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1409715/
https://ncbi.nlm.nih.gov/pubmed/16467844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600998
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