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Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
Hypoxia has recently been shown to activate the endoplasmic reticulum kinase PERK, leading to phosphorylation of eIF2α and inhibition of mRNA translation initiation. Using a quantitative assay, we show that this inhibition exhibits a biphasic response mediated through two distinct pathways. The firs...
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| Asıl Yazarlar: | , , , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2006
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1409715/ https://ncbi.nlm.nih.gov/pubmed/16467844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600998 |
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