The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

Tumor hypoxia is a common microenvironmental factor that adversely influences tumor phenotype and treatment response. Cellular adaptation to hypoxia occurs through multiple mechanisms, including activation of the unfolded protein response (UPR). Recent reports have indicated that hypoxia activates a...

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Detaylı Bibliyografya
Asıl Yazarlar: Rouschop, Kasper M.A., van den Beucken, Twan, Dubois, Ludwig, Niessen, Hanneke, Bussink, Johan, Savelkouls, Kim, Keulers, Tom, Mujcic, Hilda, Landuyt, Willy, Voncken, Jan Willem, Lambin, Philippe, van der Kogel, Albert J., Koritzinsky, Marianne, Wouters, Bradly G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2009
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798689/
https://ncbi.nlm.nih.gov/pubmed/20038797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40027
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