Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers

Interaction mapping is a powerful strategy to elucidate the biological function of protein assemblies and their regulators. Here, we report the generation of a quantitative interaction network, directly linking 14 human proteins to the AAA+ ATPase p97, an essential hexameric protein with multiple ce...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Arumughan, Anup, Roske, Yvette, Barth, Carolin, Forero, Laura Lleras, Bravo-Rodriguez, Kenny, Redel, Alexandra, Kostova, Simona, McShane, Erik, Opitz, Robert, Faelber, Katja, Rau, Kirstin, Mielke, Thorsten, Daumke, Oliver, Selbach, Matthias, Sanchez-Garcia, Elsa, Rocks, Oliver, Panáková, Daniela, Heinemann, Udo, Wanker, Erich E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080433/
https://ncbi.nlm.nih.gov/pubmed/27762274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13047
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