Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin-mimicking polyanionic compound.

Heparan sulfate (HS) proteoglycans play a key role in cell proliferation induced by basic fibroblast growth factor (FGF-2) and other heparin-binding growth factors. To modulate the involvement of HS, we have used a synthetic, nonsulfated polyanionic aromatic compound (RG-13577) that mimics functiona...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Miao, H Q, Ornitz, D M, Aingorn, E, Ben-Sasson, S A, Vlodavsky, I
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 1997
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Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507976/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9120000/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119319
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