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Structural basis of selectivity and neutralizing activity of a TGFα/epiregulin specific antibody

Recent studies have implicated a role of the epidermal growth factor receptor (EGFR) pathway in kidney disease. Skin toxicity associated with therapeutics which completely block the EGFR pathway precludes their use in chronic dosing. Therefore, we developed antibodies which specifically neutralize t...

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Publicat a:Protein Sci
Autors principals: Boyles, Jeffrey S., Atwell, Shane, Druzina, Zhanna, Heuer, Josef G., Witcher, Derrick R.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079263/
https://ncbi.nlm.nih.gov/pubmed/27543934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3023
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