Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

Clear cell renal cell carcinoma (ccRCC) is characterized by loss of function of the von Hippel–Lindau tumour suppressor (VHL) and unrestrained activation of hypoxia-inducible transcription factors (HIFs). Genetic and epigenetic determinants have an impact on HIF pathways. A recent genome-wide associ...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Grampp, Steffen, Platt, James L., Lauer, Victoria, Salama, Rafik, Kranz, Franziska, Neumann, Viviana K., Wach, Sven, Stöhr, Christine, Hartmann, Arndt, Eckardt, Kai-Uwe, Ratcliffe, Peter J., Mole, David R., Schödel, Johannes
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079059/
https://ncbi.nlm.nih.gov/pubmed/27774982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13183
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars