Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells.

Prolonged poor glycemic control in non-insulin-dependent diabetes mellitus patients often leads to a decline in insulin secretion from pancreatic beta cells, accompanied by a decrease in the insulin content of the cells. As a step toward elucidating the pathophysiological background of the so-called...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Matsuoka, T, Kajimoto, Y, Watada, H, Kaneto, H, Kishimoto, M, Umayahara, Y, Fujitani, Y, Kamada, T, Kawamori, R, Yamasaki, Y
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 1997
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507778/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9011569/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119126
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