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Involvement of Oxidative Stress in Suppression of Insulin Biosynthesis under Diabetic Conditions

Type 2 diabetes is characterized by pancreatic β-cell dysfunction and insulin resistance, and the number of patients has markedly increased worldwide. In the diabetic state, hyperglycemia per se and subsequent induction of oxidative stress decrease insulin biosynthesis and secretion, leading to the...

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Detalhes bibliográficos
Main Authors: Kaneto, Hideaki, Matsuoka, Taka-aki
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International (MDPI) 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497347/
https://ncbi.nlm.nih.gov/pubmed/23202973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms131013680
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