DNA cleavage induced by glycation of Cu,Zn-superoxide dismutase.

Human Cu,Zn-superoxide dismutase (Cu,Zn-SOD) undergoes site-specific and random fragmentation by non-enzymic glycosylation (glycation). Released Cu2+ from the glycated Cu,Zn-SOD probably facilitates a Fenton reaction to convert H2O2 into hydroxy radical, which then participates in the non-specific f...

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Autori principali: Kaneto, H, Fujii, J, Suzuki, K, Kasai, H, Kawamori, R, Kamada, T, Taniguchi, N
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1994
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1137475/
https://ncbi.nlm.nih.gov/pubmed/7998936
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