Characterization of SR 121463A, a highly potent and selective, orally active vasopressin V2 receptor antagonist.

SR 121463A, a potent and selective, orally active, nonpeptide vasopressin V2 receptor antagonist, has been characterized in several in vitro and in vivo models. This compound displayed highly competitive and selective affinity for V2 receptors in rat, bovine and human kidney (0.6 < or = Ki [nM] &...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Serradeil-Le Gal, C, Lacour, C, Valette, G, Garcia, G, Foulon, L, Galindo, G, Bankir, L, Pouzet, B, Guillon, G, Barberis, C, Chicot, D, Jard, S, Vilain, P, Garcia, C, Marty, E, Raufaste, D, Brossard, G, Nisato, D, Maffrand, J P, Le Fur, G
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507737/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8981918/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119098
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