Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V1a receptors.

SR 49059, a new potent and selective orally active, nonpeptide vasopressin (AVP) antagonist has been characterized in several in vitro and in vivo models. SR 49059 showed high affinity for V1a receptors from rat liver (Ki = 1.6 +/- 0.2) and human platelets, adrenals, and myometrium (Ki ranging from...

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Detalhes bibliográficos
Main Authors: Serradeil-Le Gal, C, Wagnon, J, Garcia, C, Lacour, C, Guiraudou, P, Christophe, B, Villanova, G, Nisato, D, Maffrand, J P, Le Fur, G
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC293574/
https://ncbi.nlm.nih.gov/pubmed/8392086
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