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Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V1a receptors.

SR 49059, a new potent and selective orally active, nonpeptide vasopressin (AVP) antagonist has been characterized in several in vitro and in vivo models. SR 49059 showed high affinity for V1a receptors from rat liver (Ki = 1.6 +/- 0.2) and human platelets, adrenals, and myometrium (Ki ranging from...

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主要な著者: Serradeil-Le Gal, C, Wagnon, J, Garcia, C, Lacour, C, Guiraudou, P, Christophe, B, Villanova, G, Nisato, D, Maffrand, J P, Le Fur, G
フォーマット: Artigo
言語:Inglês
出版事項: 1993
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC293574/
https://ncbi.nlm.nih.gov/pubmed/8392086
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