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Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V1a receptors.

SR 49059, a new potent and selective orally active, nonpeptide vasopressin (AVP) antagonist has been characterized in several in vitro and in vivo models. SR 49059 showed high affinity for V1a receptors from rat liver (Ki = 1.6 +/- 0.2) and human platelets, adrenals, and myometrium (Ki ranging from...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Serradeil-Le Gal, C, Wagnon, J, Garcia, C, Lacour, C, Guiraudou, P, Christophe, B, Villanova, G, Nisato, D, Maffrand, J P, Le Fur, G
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 1993
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC293574/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8392086/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116554
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