Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival

We have asked how the common S34F mutation in the splicing factor U2AF1 regulates alternative splicing in lung cancer, and why wild-type U2AF1 is retained in cancers with this mutation. A human lung epithelial cell line was genetically modified so that U2AF1S34F is expressed from one of the two endo...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Fei, Dennis Liang, Motowski, Hayley, Chatrikhi, Rakesh, Prasad, Sameer, Yu, Jovian, Gao, Shaojian, Kielkopf, Clara L., Bradley, Robert K., Varmus, Harold
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077151/
https://ncbi.nlm.nih.gov/pubmed/27776121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006384
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