SF1 Phosphorylation Enhances Specific Binding to U2AF(65) and Reduces Binding to 3′-Splice-Site RNA

Splicing factor 1 (SF1) recognizes 3′ splice sites of the major class of introns as a ternary complex with U2AF(65) and U2AF(35) splicing factors. A conserved SPSP motif in a coiled-coil domain of SF1 is highly phosphorylated in proliferating human cells and is required for cell proliferation. The U...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Chatrikhi, Rakesh, Wang, Wenhua, Gupta, Ankit, Loerch, Sarah, Maucuer, Alexandre, Kielkopf, Clara L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2016
Assuntos:
Nucleic Acids and Genome Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192697/
https://ncbi.nlm.nih.gov/pubmed/28002734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.11.007
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