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Regulation of Human Endonuclease V Activity and Relocalization to Cytoplasmic Stress Granules

Endonuclease V (EndoV) is an enzyme with specificity for inosines in nucleic acids. Whereas the bacterial homologs are active on both DNA and RNA, the mammalian variants only cleave RNA, at least when assayed with recombinant proteins. Here we show that ectopically expressed, as well as endogenously...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Nawaz, Meh Sameen, Vik, Erik Sebastian, Berges, Natalia, Fladeby, Cathrine, Bjørås, Magnar, Dalhus, Bjørn, Alseth, Ingrun
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076846/
https://ncbi.nlm.nih.gov/pubmed/27573237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.730911
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